Laboratory for Analytical Chemistry
Innovation of Chemical Sensors
Faculty of Science and Technology
Department of Applied Chemistry
Stimuli-responsive polymers are getting attention as next-generation medical materials because they are able to reversibly change their properties in response to external stimuli. We develop new stimuli-responsive polymers, especially those responding to changes in temperature or pH, and apply them to the medical field.
Hyperthermia, which is used for local heat treatment of cancer, provides higher therapeutic effects by combination with tumor-specific chemotherapy using thermo-responsive polymers. In this case, thermo-responsive polymers are required to be biocompatible and to show an accurate temperature response. We developed thermo-responsive polymers with high biocompatibility and a controlled response temperature close to body temperature.
pH-responsive polymer micelles
As cancer cells have a lower pH environment than normal cells, pH-responsive polymer micelles encapsulating fluorescent dyes release them selectively around cancer cells. This makes them a useful material for cancer selective fluorescent imaging. We developed pH-responsive polymer micelles with controlled pH response and succeeded in increasing the fluorescence intensity in the low pH environment.
pH-responsive mixed-charge polymers
As cell membranes have a phospholipid bilayer structure, the cell surface is negatively charged. Therefore, polymers that are positively charged in a low pH environment can selectively adsorb onto cancer cells. We developed polymers switching from a mixed charge to a positive charge state in response to low pH environment and succeeded in increasing their cell adhesion ability.
In addition, we are developing a novel thermo-responsive polymer with high biocompatibility and hydrogels for cell separation technology.
For specific information, please refer to our list of publications.
Citterio Laboratory 2022
Last update: March 08, 2022