高橋大介准教授 - Toshima・Takahashi Lab.

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高橋大介准教授　(Prof. Daisuke Takahashi) [English page]

高橋大介 (タカハシダイスケ) Takahashi, Daisuke

所属

慶應義塾大学
理工学部応用化学科
理工学研究科基礎理工学専攻生物化学専修
分子生命化学研究室

連絡先

〒223-8522
横浜市港北区日吉3-14-1
慶應義塾大学理工学部応用化学科
TEL 045(566)1537 FAX 045(566)1537
E-mail: dtak@applc.keio.ac.jp
23棟605号室

経歴

2001年　　東京工業大学工学部化学工学科応用化学コース卒業
2001年　　東京工業大学大学院理工学研究科応用化学専攻修士課程入学
2003年　　東京工業大学大学院理工学研究科応用化学専攻修士課程修了
2003年　　東京工業大学大学院理工学研究科応用化学専攻博士課程入学
2005年　　独立行政法人　日本学術振興会特別研究員（DC2）
2006年　　東京工業大学大学院理工学研究科応用化学専攻博士課程修了
　　　　　　博士(工学）取得（高橋孝志　教授）
2006年　　独立行政法人　日本学術振興会特別研究員（PD）
2007年　　デンマーク国　カールスバーグ研究所博士研究員（Ole Hindsgaul 教授）
2008年　　慶應義塾大学理工学部応用化学科助教(有期)
2011年　　同助教
2012年　　同専任講師
2016年　　同准教授

学会

日本化学会、有機合成化学協会、日本糖質学会、日本ケミカルバイオロジー学会
アメリカ化学会、日本油化学会、FCCA (Forum: Carbohydrates Coming of Age)

専門分野

糖質化学、有機合成化学、ケミカルバイオロジー

受賞

2009年　　日本化学会第89春季年会「優秀講演賞（学術）」
2015年　　有機合成化学協会研究企画「カネカ」賞
2015年　　東京糖鎖研究会奨励賞
2016年　　若い世代の特別講演会　講演証
2016年　　日本糖質学会奨励賞
2017年　　有機合成化学奨励賞
2021年　　The Carbohydrate Research Award
2022年　　オレオマテリアル賞
2023年　　Asian Core Program Lectureship Award（Singapore）

担当授業

大学院：糖質生命化学特論
学部３年生：分子生命化学２、応用化学実験第２
学部２年生：生体物質化学基礎
学部１年生：自然科学実験(化学）

研究紹介動画

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研究業績

1. 原著論文

K. Hosomi, B. Imai, N. Takemura, K. Senoo, C. Hayashi, M. Igarashi, *K. Toshima, *D. Takahashi
Total Synthesis of Kanamycins
Chem. Eur. J. 2025, accepted.

J. Meng, M. Sagawa, *K. Toshima, *D. Takahashi
Stereoselective Total Synthesis of α-Galacto-Oligosaccharides Using Boron-Mediated Aglycon Delivery and Evaluation of Their Immune-Enhancing Activities
ChemBioChem 2025, accepted.

H. Shigeta, S. Goi, D. Takahashi, *K. Toshima
Photo-Induced Glycosylation Using Edible Polyphenol Ellagic Acid
Carbohydr. Res. 2025, 552, 109461.

Y. Isozaki, T. Makikawa, K. Kimura, D. Nishihara, M. Fujino, Y. Tanaka, C. Hayashi, Y. Ishizaki, *M. Igarashi, *T. Yokoyama, *K. Toshima, *D. Takahashi
Creation of a New Macrolide Antibiotic against Non-tuberculous Mycobacterium Using Late-stage Boron-mediated Aglycon Delivery
Science Adv. 2025, 11, eadt2352.
This paper was press-released from Keio University. (☞link)

F. Ishida, S. Moriya, D. Takahashi, *K. Toshima,
A Novel Porphyrin-Based Theranostic Agent Activated by Cysteine Over-Expressed in Cancer Cells Shows Promise for Tumour-Targeted Monitoring and Phototherapy
Bioorg. Med. Chem. 2025, 121, 118131.

A. Sugimoto, T. Koike, Y. Kuboki, S. Komaba, S. Kosono, M. Aswathy, I. Anzai, T. Watanabe, *K. Toshima, *D. Takahashi
Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection
Angew. Chem. Int. Ed. 2025, 64, e202411760.
This paper was press-released from Keio University. (☞link)
This paper was selected as an inside back cover.
This paper was highlighted in The Penmark. (☞link)

F. Ishida, R. Onishi, D. Takahashi, *K. Toshima
A Novel Photosensitizer Based on Hypocrellin B Activated by Cysteine Over-Expressed in Cancer Cells
Org. Biomol. Chem. 2024, 22, 7187-7193.

J. Meng, C. Yasui, M. Shida, *K. Toshima, *D. Takahashi
Designed Mannosylerythritol Lipid Analogues Exhibiting both Selective Cytotoxicity against Human Skin Cancer Cells and Recovery Effects on Damaged Skin Cells
Chem. Eur. J. 2024, 30, e202401319.
This paper was selected as a cover feature.

S. Goi, H. Shigeta, D. Takahashi, *K. Toshima
Photo-Induced Glycosylation Using the Edible Polyphenol Curcumin
Org. Biomol. Chem. 2024, 22, 5546-5551.
This paper was selected as a front cover.

K. Matunaga, M. Takahashi, T. Kagaya, D. Takahashi, *K. Toshima
Discovery of a Novel Photosensitizer Based on the Enediyne Antibiotic N1999A2 and Its Application as a Glutathione-Activatable Theranostic Agent
Bull. Chem. Soc. Jpn. 2024, 97, uoae057.

K. Seki, T. Makikawa, *K. Toshima, *D. Takahashi
Synthesis and Immunological Evaluation of Escherichia Coli O1-Derived Oligosaccharide-Protein Conjugates toward Avian Pathogenic Escherichia Coli O1 Vaccine Development
Synthesis 2024, 56, 953-965.
This paper was highlighted in SYNFACT.
This paper was selected as a front cover.

K. Inaba, Y. Naito, M. Tachibana, *K. Toshima, *D. Takahashi
Regioselective and Stereospecific β-Arabinofuranosylation by Boron-Mediated Aglycon Delivery
Angew. Chem. Int. Ed. 2023, 62, e202307015.
This paper was selected as a front cover.
This paper was press-released from Keio University. (☞link)

N. Otani, K. Higashiyama, H. Sakai, T. Hasobe, *D. Takahashi, *K. Toshima
Photoinduced Glycosylation Using a Diarylthiophene as an Organo Lewis Photoacid Catalyst
Eur. J. Org. Chem. 2023, 26, e202300287.

S. Yoshimoto, T. Suzuki, N. Otani, D. Takahashi, K. Toshima, N. Dohmae, *S. Simizu
Destabilization of Vitelline Membrane Outer Layer Protein 1 Homolog (VMO1) by C-Mannosylation
FEBS Open Bio 2023, 13, 490-499.

T. Kondo, C. Yasui, I. Miyajima, T. Banno, K. Asakura, T. Fukuoka, K. Ushimaru, M. Koga, A. Saika, T. Morita, Y. Takahashi, C. Hayashi, M. Igarashi, *D. Takahashi, *K. Toshima
Synthesis of Mannosylerythritol Lipid Analogues and their Self-Assembling Properties, Recovery Effects on Damaged Skin Cells, and Antibacterial Activity
Chem. Eur. J. 2022, 28, e202201733.

K. Kimura, T. Yasunaga, T. Makikawa *D. Takahashi, *K. Toshima
Efficient Strategy for the Preparation of Chemical Probes of Biologically Active Glycosides Using a Boron-Mediated Aglycon Delivery (BMAD) Method
Bull. Chem. Soc. Jpn. 2022, 95, 1075-1082.

T. Kitamura, H. Nakata, *D. Takahashi, *K. Toshima
Hypocrellin B-based Activatable Photosensitizer for Specific Photodynamic Effects against High H₂O₂-Expressing Cancer Cells
Chem. Commun. 2022, 58, 242-245.
This paper was selected as an outside back cover.

T. Kondo, C. Yasui, T. Banno, K. Asakura, T. Fukuoka, K. Ushimaru, M. Koga, H. Minamikawa, A. Saika, T. Morita, *D. Takahashi, *K. Toshima
Self-Assembling Properties and Recovery Effects on Damaged Skin Cells of Chemically Synthesized Mannosylerythritol Lipids
ChemBioChem. 2022, 23, e202100631.

T. Koike, A. Sugimoto, S. Kosono, S. Komaba, Y. Kanno, T. Kitamura, I. Anzai, T. Watanabe, *D. Takahashi, *K. Toshima
Synthesis of Low-Molecular Weight Fucoidan Derivatives and Their Binding Abilities to SARS-CoV-2 Spike Proteins
RSC Med. Chem. 2021, 12, 2016-2021.

Some of the results of this paper were highlighted in Nikkan Kogyo Shimnbun on November 24, 2021. (☞link)

This paper was selected as an outside front cover.

N. Nishi, K. Seki, *D. Takahashi, *K. Toshima
Synthesis of a Pentasaccharide Repeating Unit of Lipopolysaccharide Derived from Virulent E. Coli O1 and Identification of a Glycotope Candidate of Avian Pathogenetic E. Coli O1
Angew. Chem. Int. Ed. 2021, 60, 1789-1796.

This paper was press-released from Keio University. (☞link)

This paper was selected as a Hot Paper.

This paper was selected as an inside back cover.

S. Tomita, M. Tanaka, M. Inoue, K. Inaba, *D. Takahashi, *K. Toshima
Diboron-Catalyzed Regio- and 1,2-cis-α-Stereoselective Glycosylation of trans-1,2-Diols
J. Org. Chem. 2020, 85, 16254-16262.

K. Inaba, M. Endo, N. Iibuchi, *D. Takahashi, *K. Toshima
Total Synthesis of Terpioside B
Chem. Eur. J. 2020, 26, 10222-10225.

T. Kitamura, S. Shiroshita, *D. Takahashi, *K. Toshima
2-Naphthol Moiety of Neocarzinostatin Chromophore as a Novel Protein Photodegrading Agent and Its Application as a H₂O₂-Activatable Photosensitizer
Chem. Eur. J. 2020, 26, 14351-14358.

M. Tanaka, K. Sato, R. Yoshida, N. Nishi, R. Oyamada, K. Inaba, *D. Takahashi, *K. Toshima
Diastereoselective Desymmetric 1,2-cis-Glycosylation of meso-Diols via Chirality Transfer from a Glycosyl Donor
Nat. Commun. 2020, 11, 2431. https://doi.org/10.1038/s41467-020-16365-8

This paper was press-released from Keio University. (☞link)

This paper was highlighted in Nikkei Sangyo Newspaper on September 15, 2020. (☞link)

N. Iibuchi, T. Eto, M. Aoyagi, R. Kurinami, H. Sakai, T. Hasobe, *D. Takahashi, *K. Toshima
Photo-Induced Glycosylation Using a Diaryldisulfide as an Organo-Lewis Photoacid Catalyst
Org. Biomol. Chem. 2020, 18, 851-855.

Y. Matsumoto, H. Kuriki, T. Kitamura, *D. Takahashi, *K. Toshima
Total Synthesis and Structure–Activity Relationship Study of Vineomycin A₁
J. Org. Chem. 2019, 84, 14724-14732.

T. Kitamura, M. Okuyama, *D. Takahashi, *K. Toshima
2-Phenylquinoline—Sugar Hybrids as Photo-switchable α-Glucosidase Inhibitors
Chem. Asian J. 2019, 14, 1409-1412.

S. Sotokawa, T. Kitamura, D. Takahashi, *K. Toshima
An Anthraquinone—Enzyme—Peptide Hybrid as a Photo-Switchable Enzyme
Chem. Commun. 2018, 54, 10614-10617.

N. Nishi, K. Sueoka, K. Iijima, R. Sawa, *D. Takahashi, *K. Toshima
Stereospecific β-L-Rhamnopyranosylation through an S_Ni-Type Mechanism by Using Organoboron Reagents
Angew. Chem. Int. Ed. 2018, 57, 13858-13862.
This paper was press-released from Keio University. (☞link)
This paper was highlighted as a Spotlight-Research in Chem-Station. (☞link)

S. Kosono, A. Kasai, S. Komaba, T. Matsubara, T. Sato, *D. Takahashi, *K. Toshima
Novel Hemagglutinin-Binding Sulfated Oligofucosides and Their Effect on Influenza Virus Infection
Chem. Commun. 2018, 54, 7467-7470.

J. Nashida, N. Nishi, Y. Takahashi, M. Igarashi, C. Hayashi, *D. Takahashi, *K. Toshima
Systematic and Stereoselective Total Synthesis of Mannosylerythritol Lipids and Evaluation of their Antibacterial Activity
J. Org. Chem. 2018, 83, 7281-7289.

M. Tanaka, A. Nakagawa, N. Nishi, K. Iijima, R. Sawa, *D. Takahashi, *K. Toshima
Boronic-Acid-Catalyzed Regioselective and 1,2-cis-Stereoselective Glycosylation of Unprotected Sugar Acceptors via S_Ni-Type Mechanism
J. Am. Chem. Soc. 2018, 140, 3644-3651.

R. Takagi, A. Takeda, *D. Takahashi, *K. Toshima
Target-Selective Fluorescence Imaging and Photo-Cytotoxicity against H₂O₂ High-Expressing Cancer Cells Using a Photoactivatable Theranostic Agent
Chem. Asian J. 2017, 12, 2656-2659.

N. Nishi, J. Nashida, E. Kaji, *D. Takahashi, *K. Toshima
Regio- and Stereoselective β-Mannosylation Using a Boronic Acid Catalyst and Its Application to the Synthesis of a Tetrasaccharide Repeating Unit of Lipopolysaccharide Derived from E. Coli O75
Chem. Commun. 2017, 53, 3018-3021.

S. Kusumi, H. Nakayama, T. Kobayashi, H. Kuriki, Y. Matsumoto, D. Takahashi, *K. Toshima
Total Synthesis of Aquayamycin
Chem. Eur. J. 2016, 22, 18733-18736.
This paper was selected as a Hot Paper.

M. Tanaka, *D. Takahashi, *K. Toshima
1,2-cis-α-Stereoselective Glycosylation Utilizing a Glycosyl-Acceptor-Derived Borinic Ester and Its Application to the Total Synthesis of Natural Glycosphingolipids
Org. Lett. 2016, 18, 5030-5033.

T. Kimura, T. Eto, D. Takahashi, *K. Toshima
Stereocontrolled Photo-induced Glycosylation Using an Aryl Thiourea as an Organophotoacid
Org. Lett. 2016, 18, 3190-3193.

D. Takahashi, T. Nagao, S. Sotokawa, *K. Toshima
Target-Selective Photo-Degradation of a Sialyl Lewis A (sLe^a) Conjugate and Photo-Cytotoxicity against sLe^a Positive Cancer Cells Using an Anthraquinone-Antibody Hybrid
Med. Chem. Commun. 2016, 7, 1224-1228.

M. Tanaka, J. Nashida, *D. Takahashi, *K. Toshima
Glycosyl-Acceptor-Derived Borinic Ester-Promoted Direct and β-Stereoselective Mannosylation with a 1,2-Anhydromannose Donor
Org. Lett. 2016, 18, 2288-2291.

M. Okuyama, H. Ueno, Y. Kobayashi, H. Kawagishi, D. Takahashi, *K. Toshima
Target-Selective Photo-Degradation of AFP-L3 and Selective Photo-Cytotoxicity against HuH-7 Hepatocarcinoma Cells Using an Anthraquinone-PhoSL Hybrid
Chem. Commun. 2016, 52, 2169-2172.

T. Kimura, D. Takahashi, *K. Toshima
Glycosylations of Glycals Using N-Iodosuccinimide (NIS) and Phosphorus Compounds for Syntheses of 2-Iodo- and 2-Deoxyglycosides
J. Org. Chem. 2015, 80, 9552-9562.

A. Kasai, S. Arafuka, N. Koshiba, *D. Takahashi, *K. Toshima
Systematic Synthesis of Low-Molecular Weight Fucoidan Derivatives and Their Effect on Cancer Cells
Org. Biomol. Chem. 2015, 13, 10556-10568.

M. Aoyagi, T. Kimura, A. Ohba, Y. Katayama, D. Takahashi, *K. Toshima
One-pot Transformation of N-Succinyl Chitosan to Nitrogen-containing Alkyl Glycosides Using an Ionic Liquid Containing a Protic Acid
Chem. Lett. 2015, 44, 1467-1469.

A. Nakagawa, M. Tanaka, S. Hanamura, *D. Takahashi, *K. Toshima
Regioselective and 1,2-cis-α-Stereoselective Glycosylation Utilizing Glycosyl-Acceptor-Derived Boronic Ester Catalyst
Angew. Chem. Int. Ed. 2015, 54, 10935-10939.

K. Sato, *Y. Oaki, D. Takahashi, K. Toshima, *H. Imai
Hierarchical CaCO₃ Chromatography: A Stationary Phase Based on Biominerals
Chem. Eur. J. 2015, 21, 5034-5040.

D. Kuwahara, T. Hasumi, H. Kaneko, M. Unno, *D. Takahashi, *K. Toshima
A Solid-phase Affinity Labeling Method for Target-selective Isolation and Modification of Proteins
Chem. Commun. 2014, 50, 15601-15604.

H. Ikeda, E. Kaneko, S. Okuzawa, D. Takahashi, *K. Toshima
Chemical and Biological Evaluation of Unusual Sugars, α-Aculosides, as Novel Michael Acceptors
Org. Biomol. Chem. 2014, 12, 8832-8835.

R. Iwata, K. Uda, D. Takahashi, *K. Toshima
Photo-induced Glycosylation Using Reusable Organophotoacids
Chem. Commun. 2014, 50, 10695-10698.

S. Arafuka, N. Koshiba, *D. Takahashi, *K. Toshima
Systematic Synthesis of Sulfated Oligofucosides and Their Effect on Breast Cancer MCF-7 Cells
Chem. Commun. 2014, 50, 9831-9834.
This paper was selected as an inside front cover.

A. Hirabayashi, Y. Shindo, K. Oka, D. Takahashi, *K. Toshima
Photodegradation of Amyloid β and Reduction of Its Cytotoxicity to PC12 Cells Using Porphyrin Derivatives
Chem. Commun. 2014, 50, 9543-9546.

S. Kusumi, S. Tomono, S. Okuzawa, E. Kaneko, T. Ueda, K. Sasaki, D. Takahashi, *K. Toshima
Total synthesis of Vineomycin B2
J. Am. Chem. Soc. 2013, 135, 15909-15912.

T. Kimura, M. Sekine, D. Takahashi, *K. Toshima
Chiral Brønsted Acid-mediated Glycosylation with Recognition of Alcohol Chirality
Angew. Chem. Int. Ed. 2013, 52, 12131-12134.

H. Ueno, T. Iwata, N. Koshiba, *D. Takahashi, *K. Toshima
Design, Synthesis and Evaluation of a Boronic Acid Based Artificial Receptor for L-DOPA in Aqueous Media
Chem. Commun. 2013, 49, 10403-10405.

M. Sekine, T. Kimura, Y. Katayama, D. Takahashi, *K. Toshima
The Direct and One-pot Transformation of Xylan into the Biodegradable Surfactants, Alkyl Xylosides, is Aided by an Ionic Liquid
RSC Adv. 2013, 3, 19756-19759.

M. Nakanishi, D. Takahashi, *K. Toshima
Light-induced O-Glycosylation of Unprotected Deoxythioglycosyl Donors
Org. Biomol. Chem. 2013, 11, 5079-5082.

A. Okochi, S. Tanimoto, D. Takahashi, *K. Toshima
Target-selective Photo-degradation of Verotoxin-1 and Reduction of Its Cytotoxicity to Vero Cells Using Porphyrin-globotriose Hybrids
Chem. Commun. 2013, 49, 6027-6029.

A. Takada, K. Uda, T. Ohtani, S. Tsukamoto, D. Takahashi, *K. Toshima
Improved Total Synthesis of Incednam
J. Antibiot. 2013, 66, 155-159.

Y. Aoki, S. Tanimoto, D. Takahashi, *K. Toshima
Photodegradation and Inhibition of Drug-Resistant Influenza Virus Neuraminidase Using Anthraquinone-Sialic Acid Hybrids
Chem. Commun. 2013, 49, 1169-1171.

M. Nishibu, D. Takahashi, *K. Toshima
Carbohydrate Recognition and Photodegradation by an Anthracene-Kemp’s acid hybrid
Org. Biomol. Chem. 2012, 10, 8393-8395.

D. Takahashi, T. Miura, *K. Toshima
Photodegradation of lipopolysaccharides and the Inhibition of Macrophage Activation by Anthraquinone–boronic Acid Hybrids
Chem. Commun. 2012, 48, 7595-7597.

S. Tanimoto, S. Sakai, E. Kudo, S. Okada, S. Matsumura, D. Takahashi, *K. Toshima
Target-Selective Photodegradation of HIV-1 Protease and Inhibition of HIV-1 Replication in Living Cells by Designed Fullerene–Sugar Hybrids
Chem. Asian J. 2012, 7, 911-914.

M. Takeiri, K. Horie, D. Takahashi, M. Watanabe, R. Horie, S. Simizu, K. Umezawa
Involvement of DNA Binding Domain in the Cellular Stability and Importin Affinity of NF-κB Component RelB
Org. Biomol. Chem. 2012, 10, 3053-3059.

Y. Imai, S. Hirono, H. Matsuba, T. Suzuki, Y. Kobayashi, H. Kawagishi, D. Takahashi, *K.Toshima
Degradation of Target Oligosaccharides by Anthraquinone-lectin Hybrids with Light Switching
Chem. Asian J. 2012, 7, 97-104.

T. Ohtani, S. Sakai, A. Takada, D. Takahashi, *K. Toshima
Efficient and Stereoselective Synthesis of the Disaccharide Fragment of Incednine
Org. Lett. 2011, 13, 6126-6129.

D. Takahashi, S. Hirono, *K. Toshima
Target-selective Photodegradation of Oligosaccharides by a Fullerene-boronic Acid Hybrid upon Visible Light Irradiation
Chem. Commun. 2011, 47, 11712-11714.

Y. Ishida, T. Fujii, K. Oka, D. Takahashi, *K. Toshima
Inhibition of Amyloid &beta Aggregation and Cytotoxicity by Photo-degradation Using a Designed Fullerene Derivative
Chem. Asian J. 2011, 6, 2312-2315.

K. Tsumura, A. Suzuki, T. Tsuzuki, S. Tanimoto, H. Kaneko, S. Matsumura, M. Imoto, K. Umezawa, D. Takahashi, *K. Toshima
Molecular Design, Chemical Synthesis, and Biological Evaluation of Agents that Selectively Photo-degrade the Transcription Factor Estrogen Receptor-&alpha
Org. Biomol. Chem. 2011, 9, 6357-6366.

S. Tomono, S. Kusumi, D. Takahashi, *K. Toshima
Armed-disarmed effect of remote protecting group on the glycosylation reaction of 2,3-dideoxyglycosyl donors
Tetrahedron Lett. 2011, 52, 2399-2403.

D. Takahashi, S. Hirono, C. Hayashi, M. Igarashi, Y. Nishimura, *K. Toshima
Target-selective Photodegradation of Oligosaccharides by Light-activated Small Molecules
Angew. Chem. Int. Ed. 2010, 49, 10096-10100.

T. Ohtani, S. Tsukamoto, H. Kanda, K. Misawa, Y. Urakawa, T. Fujimaki, M. Imoto, Y. Takahashi, D. Takahashi, *K. Toshima
Total synthesis of incednam, the aglycon of incednine
Org. Lett. 2010, 12, 5068-5071.

Y. Kuroiwa, M. Sekine, S. Tomono, D. Takahashi, *K. Toshima
A novel glycosylation of inactive glycosyl donors using an ionic liquid containing a protic acid under reduced pressure conditions
Tetrahedron Lett. 2010, 51, 6294-6297.

Y. Ishida, S. Tanimoto, D. Takahashi, *K. Toshima
Photo-degradation of amyloid β by a designed fullerene–sugar hybrid
Med. Chem. Commun. 2010, 1, 212-215.

S. Kusumi, K. Sasaki, S. Wang, T. Watanabe, D. Takahashi, *K. Toshima
Effective and Chemoselective glycosylations using 2,3-unsaturated sugars
Org. Biomol. Chem. 2010, 8, 3164-3178.

S. Kusumi, S. Wang, T. Watanabe, K. Sasaki, D. Takahashi, *K. Toshima
Chemoselective glycosylations using 2,3-unsaturated-4-keto glycosyl donors
Org. Biomol. Chem., 2010, 8, 988-990.

D. Takahashi, S. Kobayashi, K. Tsumura, *K. Toshima
Hydrolysis of disaccharides by metal species in neutral homogeneous conditions
Chem. Lett. 2009, 38, 728-729.

S. Tanimoto, S. Sakai, S. Matsumura, D. Takahashi, *K. Toshima
Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid
Chem. Commun. 2008, 5767-5769.

D. Takahashi, H. Tanaka, E. Nakane, *T. Takahashi
The Synthesis of Carbohydrate Microarrays by S-Alkylation of the Glass-supported 2-Bromoacetamides
Chem. Lett. 2008, 37, 1252-1253.

H. Tanaka, D. Takahashi, *T. Takahashi
Stereoselective Synthesis of Oligo-α(2,8)-3-deoxy-D-manno-2-octulosonic Acid Derivatives
Angew. Chem. Int. Ed. 2006, 45, 770-773.

H. Tanaka, Y. Iwata, D. Takahashi, M. Adachi, *T. Takahashi
Efficient Stereoselective Synthesis of γ-N-Glycosyl Asparagines by N-Glycosylation of Primary Amide Groups
J. Am. Chem. Soc. 2005, 127, 1630-1631.

T. Amaya, D. Takahashi, H. Tanaka, *T. Takahashi
Synthesis of 2,3,6-Trideoxysugar-containing Disaccharides by Cyclization and Glycosidation through the Sequential Activation of Sulfoxide and Methylsulfanyl Groups in a One-pot Procedure
Angew. Chem. Int. Ed. 2003, 42, 1833-1836.

2. 著書・総説・その他

Y. Isozaki, K. Toshima, D. Takahashi, Boron-Mediated Aglycon Delivery for Late-Stage Modifications: Applications in Chemical Biology and Pharmaceutical Lead Development
Chem. Lett., 2025, accepted.
孟継坤, 戸嶋一敦, 高橋大介, 高機能性化粧品素材の創製を指向したマンノシルエリスリトールリピッド（MEL）類縁体の合成と構造活性相関研究
オレオサイエンス, 2024, 24, 475-481.
高橋大介, 戸嶋一敦, ホウ素媒介アグリコン転移反応の新展開：反応開発、有用糖質合成、およびケミカルバイオロジーへの応用
有機合成化学協会誌, 2024, 82, 856-866.
D. Takahashi, K. Toshima, Complex Oligosaccharides Synthesis—Challenges and Tactics
In Modern Natural Product Synthesis -Overcoming Difficulties, M. Nakada, K. Tanino, K. Nagasawa, S. Yokoshima (Eds.), Springer Nature, 2024, 299-318.
D. Takahashi, K. Toshima, Total Synthesis of Mannosylerythritol Lipids and Structure-Function Relationship Studies
J. Oleo Sci., 2024, 73, 539-546.
K. Toshima, D. Takahashi, Y. Isozaki, Photo-Induced Glycosylations Using Organophotoacids: A New Environmentally Benign Carbohydrate Synthesis
Synlett, 2024, 35, 777-788.
高橋大介, 有機化学を基盤とした鳥類病原性大腸菌に対する複合糖質ワクチン開発への挑戦
日生研たより, 一般財団法人日本生物科学研究所, 2023, Vol. 69, No. 2, 3-11.
D. Takahashi, K. Toshima, Boron-mediated aglycon delivery (BMAD) for the stereoselective synthesis of 1,2-cis glycosides
Adv. Carbohydr. Chem. Biochem., 2022, 82, 79-105.
D. Takahashi, K. Inaba, K. Toshima, Recent advances in boron-mediated aglycon delivery (BMAD) for the efficient synthesis of 1,2-cis-glycosides
Carbohyrdr. Res., 2022, 518, 108579.
戸嶋一敦, 高橋大介, 有機光酸触媒を用いた光グリコシル化
バイオインダストリー, シーエムシー出版, 2021, Vol. 38, No. 8, 32-41.
高橋大介, 戸嶋一敦, ホウ素媒介アグリコン転移反応と病原菌糖鎖合成への応用
バイオインダストリー, シーエムシー出版, 2021, Vol. 38, No. 8, 3-11.
高橋大介, 【ディビジョン・トピックス】化学合成を駆使したワクチン開発への挑戦
化学と工業, 2021, 74, 513.
D. Takahashi, K. Toshima, 1,2-cis O-Glycosylation methods
In Comprehensive Glycoscience 2nd edition, J. J. Barchi (Ed.), Elsevier, Vol. 2, 2021, 365-412.
高橋大介, 戸嶋一敦, マンノシルエリスリトールリピッド（MEL）の効率的全合成と抗菌活性を指標とした構造－機能相関の解明
オレオサイエンス, 2020, 20, 209-214.
高橋大介, ボロン酸触媒を活用した位置および1,2-cis-立体選択的グリコシル化反応の開発と応用
有機合成化学協会誌, 2020, 78, 221-231.
高橋大介, 戸嶋一敦, 架橋構造をもつ糖
化学, 化学同人, 2020, Vol. 75, No. 2, 72-73.
D. Takahashi, Boronic-acid-catalyzed regioselective and stereoselective glycosylations via sni-type mechanism
Trends Glycosci. Glycotechnol., 2019, 31, SE93-SE94.
高橋大介, 戸嶋一敦, アントラキノン―レクチンハイブリッド分子による標的糖タンパク質の選択的光分解
週刊医学のあゆみ, 医歯薬出版, 2019, Vol. 269, No. 9, 711-717
高橋大介, ボリン酸触媒を用いた1,2-cis-立体選択的グリコシル化反応の開発と天然物合成への応用
有機合成化学協会誌, 2018, 76, 470-473.
D. Takahashi, M. Tanaka, K. Toshima, Regioselective and stereoselective glycosylations utilizing organoboron compounds
Trends Glycosci. Glycotechnol., 2018, 30, E55-E62.
D. Takahashi, M. Tanaka, N. Nishi, K. Toshima, Novel 1,2-cis-stereoselective glycosylations utilizing organoboron reagents and their application to natural products and complex oligosaccharide synthesis
Carbohydr. Res., 2017, 452, 64-77.
D. Takahashi, Direct and stereoselective synthesis of β-mannosides by anomeric O-alkylation
Trends Glycosci. Glycotechnol., 2016, 28, E119-120.
高橋大介, 【飛翔する若手研究者】有機ホウ素化合物を利用した標的糖鎖の選択的合成と光分解
化学と工業, 2016, 69, 881-882.
K. Toshima, D. Takahashi, Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules
Glycoconj. J., 2015, 32, 475-482.
佐々木要, 高橋大介, 戸嶋一敦, 環境調和型グリコシル化反応
糖鎖の新機能開発・応用ハンドブック, エヌ・ティー・エス, 2015, 339-342.
高橋大介, 戸嶋一敦, 標的糖鎖光分解用生体機能分子
糖鎖の新機能開発・応用ハンドブック, エヌ・ティー・エス, 2015, 377-379.
D. Takahashi, Organoboron-Mediated Regio- and Stereoselective Glycosylation
Trends Glycosci. Glycotechnol., 2015, 27, 61-62.
平林歩, 石田康則, 高橋大介, 戸嶋一敦, アルツハイマー病原因物質アミロイドβを光分解する生体機能光制御分子の創製と応用
Chemical Biology, 2014, Vol. 7, 2-5.
D. Takahashi, K. Toshima, Stereoselective formation of 2-deoxy-glycosidic bonds in biologically active natural products
In Stereoselective Synthesis of Drugs and Natural Products, V. Andrushko, N. Andrushko (Eds.), Wiley-Blackwell, 2013, 1137-1171.
関根麻衣子, 高橋大介, 戸嶋一敦, イオン液体を用いたバイオマス糖質からの配糖体合成
機能性配糖体の合成と応用－糖転移酵素を中心に－, シーエムシー出版, 2013, 115-123.
D. Takahashi, K. Toshima, Chemistry based approach for degradation of target-oligosaccharides using photo-activatable organic small molecules
Trends Glycosci. Glycotechnol., 2012, 24, 258-276.
K. Toshima, D. Takahashi, S. Tanimoto, Creation of novel biofunctional molecules for target-selective photodegradation of proteins and carbohydrates: a synthetic and chemical, biological study for the post-genome era
J. Synth. Org. Chem. Jpn, 2012, 70, 1187-1195.
谷本周穂, 高橋大介, 戸嶋一敦, エイズの原因物質を光で狙い撃ち
光アライアンス, 日本工業出版, 2012, Vol. 23, No. 8, 50-53
S. Tanimoto, D. Takahashi, K. Toshima, Chemical methods for degradation of target proteins using designed light-activatable organic molecules
Chem. Commun., 2012, 48, 7659-7671.
D. Takahashi, K. Toshima, Chemical methods for degradation of target oligosaccharides using designed light-activatable organic molecules
Chem. Commun., 2012, 48, 4397-4407.
高橋大介, 戸嶋一敦, 超分子を利用した糖鎖認識：β－グルコシルを認識する人工レクチンの創製
Chemical Biology, 2010, Vol. 3, No. 3, 11.
高橋大介, 戸嶋一敦, 第三の生命鎖は制御できるか？－糖鎖の機能を人為的に操る新技術
化学, 化学同人, 2010, Vol. 65, No. 8, 74-75.
高橋大介, 戸嶋一敦, 糖鎖を認識する超分子
バイオインダストリー, シーエムシー出版, 2010, Vol. 27, No. 2, 43-48.
K. Toshima, S. Tanimoto, K. Tsumura, K. Umezawa, D. Takahashi, Target-selective degradation of cancer-related proteins by novel photo-sensitizers for molecular-targeted photodynamic therapy
Cancer Sci., 2009, 100, 1581-1584.