研究業績



論文


    2022


  1. Matsuda, Y., Koyama, T., Kawano, S., Miura, K., Simizu, S., Nakata, M. & Saikawa, Y., "Scalable Syntheses and Biological Evaluation of Africane-Type Sesquiterpenoids" Chemistry&Biodiversity 2022, 19, e202100890 doi:org/10.1002/cbdv.202100890


  2. 2021


  3. Miyazaki, S., Endo, A., Matsui, S., Tokuda, M. & Saikawa, Y., "Histological and quantitative image analyses of rice gall formed by orange Leafhopper Cicadulina bipunctata (Hemiptera:Cicadellidae) " Applied Entomology and Zoology, 2021, 56, 419–425 doi:10.1007/s13355-021-00736-8

  4. Nurkanto, A., Jeelani, G., Santos, H. J., Rahmawati, Y., Mori, M., Nakamura, Y., Goto, K., Saikawa, Y., Annoura, T., Tozawa, Y., Sakura, T., Inaoka, D. K., Shiomi, K. & Nozaki, T., "Characterization of Plasmodium falciparum Pantothenate Kinase and Identification of Its Inhibitors From Natural Products" Frontiers in Cellular and Infection Microbiology, 2021, 11, 639065 doi:10.3389/fcimb.2021.639065

  5. 2020


  6. Miyazaki, S., Kasahara, K., Matsui, S., Tokuda, M. & Saikawa, Y., "Orange Leafhopper Cicadulina bipunctata Feeding Induces Gall Formation Nitrogen Dependently and Regulates Gibberellin Signaling" Plants 2020, 9, 1270 doi:10.3390/plants9101270

  7. Ito, T., Itokawa, H., Miyaki, T., Hamano, M., Kamimura, M., Nakata, M. & Saikawa, Y., "Inositol tetrakisphosphate from chicken eggshell " Tetrahedron 2020, 76, 130853 doi:10.1016/j.tet.2019.130853

  8. Ito, T., Kato, S., Kubo, A., Suematsu, M., Nakata, M. & Saikawa, Y., "Small molecules assisting eggshell calcium dissolution for embryonic bone formation" Tetrahedron 2020, 76, 130854 doi:10.1016/j.tet.2019.130854

  9. Miyazaki, S., Kurisu, H., Nakata, M. & Saikawa, Y., "Identification of a cyanidin-3-O-β-galactoside in gall tissue induced by midges on Japanese beech (Fagus crenata Blume)" Bioscience, Biotechnology, and Biochemistry 2020, 84, 797-799, doi:10.1080/09168451.2019.1698941

  10. 2019


  11. Kim, T., Matsushita, S., Matsudaira, S., Doi, T., Hirota, S., Park, Y. T., Igarashi, M., Hatano, M., Ikeda, N., Ham, J., Nakata, M. & Saikawa, Y., "Total Synthesis of Pactalactam, an Imidazolidinone-Type Pactamycin Analogue" Organic Letters 2019, 21, 10, 3554-3557 doi:10.1021/acs.orglett.9b00905

  12. 2018


  13. Matsuda, Y., Saikawa, Y. & Nakata, M., "An overview of the total synthesis of africane-type sesquiterpenoids" 2018, Tetrahedron Letters.59, 2377-2386 doi:10.1016/j.tetlet.2018.05.048

  14. Shindo, Y., Nomura, S., Saikawa, Y., Nakata, M., Tanaka, K., Hanaya, K., Sugai, T. & Higashibayashi, S., "Synthesis and Properties of Hydrazine-Embedded Biphenothiazines and Application of Hydrazine-Embedded Heterocyclic Compounds to Fluorescence Cell Imaging" Asian Journal of Organic Chemistry 2018, 7, 1797-1801 doi:10.1002/ajoc.201800364

  15. 2016


  16. Matsuura, M., Kato, S., Saikawa, Y., Nakata, M., & Hashimoto, K., "Identification of cyclopropylacetyl-(R)-carnitine, a unique chemical marker of the fatally toxic mushroom Russula subnigricans" Chemical and Pharmaceutical Bulletin 2016, 64, p. 602–608 doi:10.1248/cpb.c15-01033

  17. 2015


  18. Matsuda, Y., Koyama, T., Kato, M., Kawaguchi, T., Saikawa, Y., & Nakata, M., "Palladium-catalyzed 6-endo-dig oxycyclization–methoxycarbonylation toward the total synthesis of polymaxenolides", Tetrahedron 2015, 71, 2134–2148 doi:10.1016/j.tet.2015.02.037

  19. Matsumoto, T., Saikawa, Y., Nakata, M., & Hashimoto, K., "Refined Structure of Hipposudoric and Norhipposudoric Acids, Pigments of the Red Sweat of the Hippopotamus" Chemistry Letters 2015, 44, 1738–1740 doi:10.1246/cl.150846

  20. 2014


  21. Adachi, S., Onozuka, M., Yoshida, Y., Ide, M., Saikawa, Y., & Nakata, M., "Smooth Isoindolinone Formation from Isopropyl Carbamates via Bischler-Napieralski-type Cyclization", Organic Letters 2014, 16, 358–361 doi:10.1021/ol403142d

  22. Matsuda, Y., Kato, M., Kawaguchi, T., Koyama, T., Saikawa, Y., & Nakata, M., "Synthetic Studies on Polymaxenolides: Model Studies for Constructing Dihydropyran Portion and Synthesis of Lower Portion", Tetrahedron 2014, 70, 1154–1168 doi:10.1016/j.tet.2013.12.076

  23. Tanaka, K., Matsuyama, H., Watanabe, M., Fujimori, Y., Ishibashi, K., Ozawa, T., Sato, T., Saikawa, Y., & Nakata, M., "Synthesis and Biological Evaluation of Kendomycin and Its Analogues", The Journal of Organic Chemistry 2014, 79, 9922–9947 doi:10.1021/jo5015273

  24. 2013


  25. Adachi, S., Watanabe, K., Iwata, Y., Kameda, S., Miyaoka, Y., Onozuka, M., Mitsui, R., Saikawa, Y., & Nakata, M., "Total Syntheses of Lactonamycin and Lactonamycin Z with Late-Stage A-Ring Formation and Glycosylation", Angewandte Chemie International Edition 2013, 52, 2087–2091 doi:10.1002/anie.201209205

  26. 2012


  27. Yamada, M., Tokumitsu, N., Saikawa, Y., Nakata, M., Asano, J., Miyairi, K., Okuno, T., Konno, K., & Hashimoto, K., "Molybdophyllysin, a toxic matalloendopeptidase from the tropical toadstool, Chlorophyllum molybdites", Bioorganic & Medicinal Chemistry 2012, 20, 6583–6588 doi:10.1016/j.bmc.2012.09.036

  28. 2011


  29. Matsuda, Y., Endo, Y., Saikawa, Y., & Nakata, M., "Synthetic Studies on Polymaxenolides: Synthesis and Structure Elucidation of Nominal Epoxyafricanane and Other Africane-type Sesquiterpenoids", The Journal of Organic Chemistry 2011, 76, 6258–6263 doi:10.1021/jo2010186

  30. 〜2010


  31. Watanabe, K., Iwata, Y., Adachi, S., Nishikawa, T., Yoshida, Y., Kameda, S., Ide, M., Saikawa, Y., & Nakata, M., "Synthetic Studies on Lactonamycins: Synthesis of the Model BCDEF Aglycon" The Journal of Organic Chemistry 2010, 75, 5573–5579 doi:10.1021/jo100913s

  32. Tanaka, K., Watanabe, M., Ishibashi, K., Matsuyama, H., Saikawa, Y., & Nakata, M., "Total Synthesis of Kendomycin Featuring Intramolecular Dötz Benzannulation", Organic Letters 2010, 12, 1700–1703 doi:10.1021/ol100229f

  33. Horibe, M., Kobayashi, Y., Dohra, H., Morita, T., Murata, T., Usui, T., Nakamura-Tsuruta, S., Kamei, M., Hirabayashi, J., Matsuura, M., Yamada, M., Saikawa, Y., Hashimoto, K., Nakata, M., & Kawagishi, H., "Toxic isolectins from the mushroom Boletus venenatus", Phytochemistry 2010, 72, 648–657 doi:10.1016/j.phytochem.2009.12.003

  34. Matsuura, M., Saikawa, Y., Inui, K., Nakae, K., Igarashi, M., Hashimoto, K., & Nakata, M., "Identification of the toxic trigger in mushroom poisoning", Nature Chemical Biology 2009, 5, 465–467 doi:10.1038/nchembio.179

  35. Okada, H., Mori, T., Saikawa, Y., & Nakata, M., "Formation of α-hydroxyketones via irregular Wittig reaction", Tetrahedron Letters 2009, 50, 1276–1278 doi:10.1016/j.tetlet.2008.12.102

  36. Tanaka, K., Fujimori, Y., Saikawa, Y., & Nakata, M., "Diastereoselective Synthesis of Useful Building Blocks by Crotylation of β-Branched α-Methylaldehydes with Potassium Crotyltrifluoroborates", The Journal of Organic Chemistry 2008, 73, 6292–6298 doi:10.1021/jo801106b

  37. Hashimoto, K., Saikawa, Y., & Nakata, M., "Studies on the red sweat of the Hippopotamus amphibious", Pure and Applied Chemistry 2007, 79, 507–517 doi:10.1351/pac200779040507

  38. Matsuura, M., Yamada, M., Saikawa, Y., Miyairi, K., Okuno, T., Konno, K., Uenishi, J., Hashimoto, K., & Nakata, M., "Bolevenine, a toxic protein from the Japanese toadstool Boletus venenatus", Phytochemistry 2007, 68, 893–898 doi:10.1016/j.phytochem.2006.11.037

  39. Mori, T., Miyagi, M., Suzuki, K., Shibasaki, M., Saikawa, Y., & Nakata, M., "Synthetic studies on chlorofusin: Synthesis of the cyclic peptide portion", Heterocycles 2007, 72, 275–291 doi:10.3987/com-06-s(k)11

  40. Watanabe, M., Tanaka, K., Saikawa, Y., & Nakata, M., "Application of intramolecular Dötz reaction to the synthesis of ansa-compounds: concise synthesis of arnebinol", Tetrahedron Letters 2007, 48, 203–206 doi:10.1016/j.tetlet.2006.11.059

  41. Saikawa, Y., Moriya, K., Hashimoto, K., & Nakata, M., "Synthesis of hipposudoric and norhipposudoric acids: the pigments responsible for the color reaction of the red sweat of Hippopotamus amphibious", Tetrahedron Letters 2006, 47, 2535−2538 doi:10.1016/j.tetlet.2006.02.042

  42. Saikawa, Y., Hashimotom K., Nakata, M., Yoshihara, M., Nagai, K., Ida, M., & Komiya, T., "The red sweat of the hippopotamus", Nature 2004, 429, 363 doi:10.1038/429363a

  43. Zhang, H.-J., Tamez, P. A., Aydogmus, Z.,Tan, G. T., Saikawa, Y., Hashimoto, K., Nakata, M., Hung, N. V., Xuan, L. T., Cuong, N. M., Soejarto, D. D., Pezzuto, J. M., & Fong, H. H. S., "Antimalarial Agents from Plants. III. Trichothecenes fron Ficus fistulosa and Rhaphidophora decursiva", Planta Medica 2002, 68, 1088−1091 doi:10.1055/s-2002-36350

  44. Saikawa, Y., Okamoto, H., Inui, T., Makabe, M., Okuno, T., Suda, T., Hashimoto, K., & Nakata, M., "Toxic principles of a poisonous mushroom Podostroma cornu-damae", Tetrahedron 2001, 57, 8277−8281 doi:10.1016/S0040-4020(01)00824-9

  45. Saikawa, Y., Watanabe, T., Hashimoto, K., & Nakata, M., "Absolute configuration and tautomeric structure of xylindein, a blue-green pigment of Chlorociboria species", Phytochemistry 2000, 55, 237−240 doi:10.1016/S0031-9422(00)00282-X


受賞関連


  1. 2015年3月 犀川陽子:第3回女性化学者奨励賞(日本化学会、平成26年度)「合成終盤の骨格形成による有用ポリケチド類の効率的合成」

  2. 2013年3月 阿部 雅義:慶應義塾義塾賞(金時計)「優秀な学業成績による」

  3. 2012年4月 安達 智史:日本化学会第92春季年会(2012) 学生講演賞 「ラクトナマイシンの全合成」

  4. 2011年3月 小野塚 正雄:慶應義塾大学理工学部応用化学科 慶應応化進歩賞 「ラクトナマイシンの合成を指向したBischler-Napieralski型5員環ラクタム合成法の開発」

  5. 2010年9月 松田 豊:日本化学会関東支部大会 学生講演賞 「海洋天然物ポリマキセノライド類のアフリカナン部分の合成」

  6. 2010年9月 金 泰亭:日本化学会関東支部大会 学生講演賞 「8置換シクロペンタン骨格を有するパクタマイシンの合成研究」

  7. 2009年4月 松浦 正憲:第89日本化学会春季年会 学生講演賞 「致死性猛毒きのこニセクロハツ (Russula subnigricans)の毒成分に関する化学的研究(2)」

  8. 2008年10月 松浦 正憲:第50回天然有機化合物討論会 奨励賞 「致死性猛毒きのこニセクロハツ (Russula subnigricans)の毒成分研究」

  9. 2007年4月 市毛 孝弘:第87日本化学会春季年会 学生講演賞 「メチルサルコフィトエートの全合成」

  10. 2003年10月 犀川 陽子:第45回天然有機化合物討論会 奨励賞 「カバの汗(分泌物)に含まれる色素の化学的研究」





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慶應義塾大学
理工学部 応用化学科
天然物有機化学研究室
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