研究業績



論文


    2022


  1. Matsuda, Y., Koyama, T., Kawano, S., Miura, K., Simizu, S., Nakata, M. & Saikawa, Y., "Scalable Syntheses and Biological Evaluation of Africane-Type Sesquiterpenoids" Chemistry & Biodiversity 2022, 19, e202100890 doi:10.1002/cbdv.202100890

    2. 2021


  2. Miyazaki, S., Endo, A., Matsui, S., Tokuda, M. & Saikawa, Y., "Histological and quantitative image analyses of rice gall formed by orange Leafhopper Cicadulina bipunctata (Hemiptera:Cicadellidae) " Applied Entomology and Zoology, 2021, 56, 419–425 doi:10.1007/s13355-021-00736-8
  3. Nurkanto, A., Jeelani, G., Santos, H. J., Rahmawati, Y., Mori, M., Nakamura, Y., Goto, K., Saikawa, Y., Annoura, T., Tozawa, Y., Sakura, T., Inaoka, D. K., Shiomi, K. & Nozaki, T., "Characterization of Plasmodium falciparum Pantothenate Kinase and Identification of Its Inhibitors From Natural Products" Frontiers in Cellular and Infection Microbiology, 2021, 11, 639065 doi:10.3389/fcimb.2021.639065

    4. 2020


  4. Miyazaki, S., Kasahara, K., Matsui, S., Tokuda, M. & Saikawa, Y., "Orange Leafhopper Cicadulina bipunctata Feeding Induces Gall Formation Nitrogen Dependently and Regulates Gibberellin Signaling" Plants 2020, 9, 1270 doi:10.3390/plants9101270
  5. Ito, T., Itokawa, H., Miyaki, T., Hamano, M., Kamimura, M., Nakata, M. & Saikawa, Y., "Inositol tetrakisphosphate from chicken eggshell " Tetrahedron 2020, 76, 130853 doi:10.1016/j.tet.2019.130853
  6. Ito, T., Kato, S., Kubo, A., Suematsu, M., Nakata, M. & Saikawa, Y., "Small molecules assisting eggshell calcium dissolution for embryonic bone formation" Tetrahedron 2020, 76, 130854 doi:10.1016/j.tet.2019.130854
  7. Miyazaki, S., Kurisu, H., Nakata, M. & Saikawa, Y., "Identification of a cyanidin-3-O-β-galactoside in gall tissue induced by midges on Japanese beech (Fagus crenata Blume)" Bioscience, Biotechnology, and Biochemistry 2020, 84, 797-799, doi:10.1080/09168451.2019.1698941

    8. 2019


  8. Kim, T., Matsushita, S., Matsudaira, S., Doi, T., Hirota, S., Park, Y. T., Igarashi, M., Hatano, M., Ikeda, N., Ham, J., Nakata, M. & Saikawa, Y., "Total Synthesis of Pactalactam, an Imidazolidinone-Type Pactamycin Analogue" Organic Letters 2019, 21, 10, 3554-3557 doi:10.1021/acs.orglett.9b00905

    9. 2018


  9. Matsuda, Y., Saikawa, Y. & Nakata, M., "An overview of the total synthesis of africane-type sesquiterpenoids" 2018, Tetrahedron Letters.59, 2377-2386 doi:10.1016/j.tetlet.2018.05.048
  10. Shindo, Y., Nomura, S., Saikawa, Y., Nakata, M., Tanaka, K., Hanaya, K., Sugai, T. & Higashibayashi, S., "Synthesis and Properties of Hydrazine-Embedded Biphenothiazines and Application of Hydrazine-Embedded Heterocyclic Compounds to Fluorescence Cell Imaging" Asian Journal of Organic Chemistry 2018, 7, 1797-1801 doi:10.1002/ajoc.201800364

    11. 2016


  11. Matsuura, M., Kato, S., Saikawa, Y., Nakata, M., & Hashimoto, K., "Identification of cyclopropylacetyl-(R)-carnitine, a unique chemical marker of the fatally toxic mushroom Russula subnigricans" Chemical and Pharmaceutical Bulletin 2016, 64, p. 602–608 doi:10.1248/cpb.c15-01033

    12. 2015


  12. Matsuda, Y., Koyama, T., Kato, M., Kawaguchi, T., Saikawa, Y., & Nakata, M., "Palladium-catalyzed 6-endo-dig oxycyclization–methoxycarbonylation toward the total synthesis of polymaxenolides", Tetrahedron 2015, 71, 2134–2148 doi:10.1016/j.tet.2015.02.037
  13. Matsumoto, T., Saikawa, Y., Nakata, M., & Hashimoto, K., "Refined Structure of Hipposudoric and Norhipposudoric Acids, Pigments of the Red Sweat of the Hippopotamus" Chemistry Letters 2015, 44, 1738–1740 doi:10.1246/cl.150846

    14. 2014


  14. Adachi, S., Onozuka, M., Yoshida, Y., Ide, M., Saikawa, Y., & Nakata, M., "Smooth Isoindolinone Formation from Isopropyl Carbamates via Bischler-Napieralski-type Cyclization", Organic Letters 2014, 16, 358–361 doi:10.1021/ol403142d
  15. Matsuda, Y., Kato, M., Kawaguchi, T., Koyama, T., Saikawa, Y., & Nakata, M., "Synthetic Studies on Polymaxenolides: Model Studies for Constructing Dihydropyran Portion and Synthesis of Lower Portion", Tetrahedron 2014, 70, 1154–1168 doi:10.1016/j.tet.2013.12.076
  16. Tanaka, K., Matsuyama, H., Watanabe, M., Fujimori, Y., Ishibashi, K., Ozawa, T., Sato, T., Saikawa, Y., & Nakata, M., "Synthesis and Biological Evaluation of Kendomycin and Its Analogues", The Journal of Organic Chemistry 2014, 79, 9922–9947 doi:10.1021/jo5015273

    17. 2013


  17. Adachi, S., Watanabe, K., Iwata, Y., Kameda, S., Miyaoka, Y., Onozuka, M., Mitsui, R., Saikawa, Y., & Nakata, M., "Total Syntheses of Lactonamycin and Lactonamycin Z with Late-Stage A-Ring Formation and Glycosylation", Angewandte Chemie International Edition 2013, 52, 2087–2091 doi:10.1002/anie.201209205

    18. 2012


  18. Yamada, M., Tokumitsu, N., Saikawa, Y., Nakata, M., Asano, J., Miyairi, K., Okuno, T., Konno, K., & Hashimoto, K., "Molybdophyllysin, a toxic matalloendopeptidase from the tropical toadstool, Chlorophyllum molybdites", Bioorganic & Medicinal Chemistry 2012, 20, 6583–6588 doi:10.1016/j.bmc.2012.09.036

    19. 2011


  19. Matsuda, Y., Endo, Y., Saikawa, Y., & Nakata, M., "Synthetic Studies on Polymaxenolides: Synthesis and Structure Elucidation of Nominal Epoxyafricanane and Other Africane-type Sesquiterpenoids", The Journal of Organic Chemistry 2011, 76, 6258–6263 doi:10.1021/jo2010186

    20. 〜2010


  20. Watanabe, K., Iwata, Y., Adachi, S., Nishikawa, T., Yoshida, Y., Kameda, S., Ide, M., Saikawa, Y., & Nakata, M., "Synthetic Studies on Lactonamycins: Synthesis of the Model BCDEF Aglycon" The Journal of Organic Chemistry 2010, 75, 5573–5579 doi:10.1021/jo100913s
  21. Tanaka, K., Watanabe, M., Ishibashi, K., Matsuyama, H., Saikawa, Y., & Nakata, M.,　"Total Synthesis of Kendomycin Featuring Intramolecular Dötz Benzannulation", Organic Letters 2010, 12, 1700–1703 doi:10.1021/ol100229f
  22. Horibe, M., Kobayashi, Y., Dohra, H., Morita, T., Murata, T., Usui, T., Nakamura-Tsuruta, S., Kamei, M., Hirabayashi, J., Matsuura, M., Yamada, M., Saikawa, Y., Hashimoto, K., Nakata, M., & Kawagishi, H., "Toxic isolectins from the mushroom Boletus venenatus", Phytochemistry 2010, 72, 648–657 doi:10.1016/j.phytochem.2009.12.003
  23. Matsuura, M., Saikawa, Y., Inui, K., Nakae, K., Igarashi, M., Hashimoto, K., & Nakata, M., "Identification of the toxic trigger in mushroom poisoning", Nature Chemical Biology 2009, 5, 465–467 doi:10.1038/nchembio.179
  24. Okada, H., Mori, T., Saikawa, Y., & Nakata, M., "Formation of α-hydroxyketones via irregular Wittig reaction", Tetrahedron Letters 2009, 50, 1276–1278 doi:10.1016/j.tetlet.2008.12.102
  25. Tanaka, K., Fujimori, Y., Saikawa, Y., & Nakata, M., "Diastereoselective Synthesis of Useful Building Blocks by Crotylation of β-Branched α-Methylaldehydes with Potassium Crotyltrifluoroborates", The Journal of Organic Chemistry 2008, 73, 6292–6298 doi:10.1021/jo801106b
  26. Hashimoto, K., Saikawa, Y., & Nakata, M., "Studies on the red sweat of the Hippopotamus amphibious", Pure and Applied Chemistry 2007, 79, 507–517 doi:10.1351/pac200779040507
  27. Matsuura, M., Yamada, M., Saikawa, Y., Miyairi, K., Okuno, T., Konno, K., Uenishi, J., Hashimoto, K., & Nakata, M., "Bolevenine, a toxic protein from the Japanese toadstool Boletus venenatus", Phytochemistry 2007, 68, 893–898 doi:10.1016/j.phytochem.2006.11.037
  28. Mori, T., Miyagi, M., Suzuki, K., Shibasaki, M., Saikawa, Y., & Nakata, M., "Synthetic studies on chlorofusin: Synthesis of the cyclic peptide portion", Heterocycles 2007, 72, 275–291 doi:10.3987/com-06-s(k)11
  29. Watanabe, M., Tanaka, K., Saikawa, Y., & Nakata, M., "Application of intramolecular Dötz reaction to the synthesis of ansa-compounds: concise synthesis of arnebinol", Tetrahedron Letters 2007, 48, 203–206 doi:10.1016/j.tetlet.2006.11.059
  30. Saikawa, Y., Moriya, K., Hashimoto, K., & Nakata, M., "Synthesis of hipposudoric and norhipposudoric acids: the pigments responsible for the color reaction of the red sweat of Hippopotamus amphibious", Tetrahedron Letters 2006, 47, 2535−2538 doi:10.1016/j.tetlet.2006.02.042
  31. Saikawa, Y., Hashimotom K., Nakata, M., Yoshihara, M., Nagai, K., Ida, M., & Komiya, T., "The red sweat of the hippopotamus", Nature 2004, 429, 363 doi:10.1038/429363a
  32. Zhang, H.-J., Tamez, P. A., Aydogmus, Z.,Tan, G. T., Saikawa, Y., Hashimoto, K., Nakata, M., Hung, N. V., Xuan, L. T., Cuong, N. M., Soejarto, D. D., Pezzuto, J. M., & Fong, H. H. S., "Antimalarial Agents from Plants. III. Trichothecenes fron Ficus fistulosa and Rhaphidophora decursiva", Planta Medica 2002, 68, 1088−1091 doi:10.1055/s-2002-36350
  33. Saikawa, Y., Okamoto, H., Inui, T., Makabe, M., Okuno, T., Suda, T., Hashimoto, K., & Nakata, M., "Toxic principles of a poisonous mushroom Podostroma cornu-damae", Tetrahedron 2001, 57, 8277−8281 doi:10.1016/S0040-4020(01)00824-9
  34. Saikawa, Y., Watanabe, T., Hashimoto, K., & Nakata, M., "Absolute configuration and tautomeric structure of xylindein, a blue-green pigment of Chlorociboria species", Phytochemistry 2000, 55, 237−240 doi:10.1016/S0031-9422(00)00282-X

受賞関連


  1. 2015年3月 犀川陽子：第３回女性化学者奨励賞（日本化学会、平成２６年度）「合成終盤の骨格形成による有用ポリケチド類の効率的合成」
  2. 2013年3月 阿部　雅義：慶應義塾義塾賞（金時計）「優秀な学業成績による」
  3. 2012年4月 安達　智史：日本化学会第92春季年会(2012)　学生講演賞 「ラクトナマイシンの全合成」
  4. 2011年3月 小野塚　正雄：慶應義塾大学理工学部応用化学科　慶應応化進歩賞 「ラクトナマイシンの合成を指向したBischler-Napieralski型5員環ラクタム合成法の開発」
  5. 2010年9月 松田　豊：日本化学会関東支部大会 学生講演賞 「海洋天然物ポリマキセノライド類のアフリカナン部分の合成」
  6. 2010年9月 金　泰亭：日本化学会関東支部大会 学生講演賞 「８置換シクロペンタン骨格を有するパクタマイシンの合成研究」
  7. 2009年4月 松浦　正憲：第89日本化学会春季年会 学生講演賞 「致死性猛毒きのこニセクロハツ (Russula subnigricans)の毒成分に関する化学的研究(2)」
  8. 2008年10月 松浦　正憲：第50回天然有機化合物討論会　奨励賞 「致死性猛毒きのこニセクロハツ (Russula subnigricans)の毒成分研究」
  9. 2007年4月 市毛　孝弘：第87日本化学会春季年会 学生講演賞 「メチルサルコフィトエートの全合成」
  10. 2003年10月 犀川　陽子：第45回天然有機化合物討論会　奨励賞 「カバの汗（分泌物）に含まれる色素の化学的研究」

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慶應義塾大学
理工学部 応用化学科
天然物有機化学研究室
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