Publications

Original Articles

  1. Kawaguchi M, Aoki H, Kamo H, Miura K, Hiruta Y, Simizu S & Citterio D. Simplified capture, extraction and amplification of cellular DNA from water samples. Anal. Sci. 40, 501-510 (2024)
  2. Baydoun H, Kato Y, Kamo H, Hüsch A, Mizuta H, Kawahara R & Simizu S. DPY19L3 promotes proliferation and vasculogenic mimicry in human cancer cell lines by its C-mannosyltransferase activity. Oncol. Res. in press
  3. Kage A, Okuyama Y, Kato E, Matagawa T, Kawano S, Simizu S, Chida N, Okamura T & Sato T. Synthesis and evaluation of saponins with all-nitrogenated sugars. Synlett 35, 427-430 (2024)
  4. Nishida H, Sasaki T, Taga Y, Murasawa Y, Simizu S, Matsushita S, Isogai Z, Hattori S, Daa T, Nagamine N, Sekine A & Fujiwara S. Presence of microfibril associated glycoprotein 4 and type V collagen and the possible absence of fibrillin-1 in bead-like structures in elastofibroma. J. Dermatol. Sci. 112, 112-116 (2023)
  5. Kawahara R, Usami T, Arakawa S, Kamo H, Suzuki T, Komatsu R, Hara H, Niwa Y, Shimizu E, Dohmae N, Shimizu S & Simizu S. Biogenesis of fibrils requires C-mannosylation of PMEL. FEBS J. 290, 5373-5394 (2023)
  6. Watanabe R, Nakachi Y, Matsubara H, Ueda J, Ishii T, Ukai W, Hashimoto E, Kasai K, Simizu S, Kato T, Bundo M & Iwamoto K. Identification of epigenetically active L1 promoters in the human brain and their relationship with psychiatric disorders. Neurosci. Res. 195, 37-51 (2023)
  7. Nakajima M, Kawahara R & Simizu S. Cofilin promotes vasculogenic mimicry by regulating actin cytoskeleton in human breast cancer cells. FEBS Lett. 597, 1114-1124 (2023)
  8. Yoshimoto S, Suzuki T, Otani N, Takahashi D, Toshima K, Dohmae N & Simizu S. Destabilization of vitelline membrane outer layer protein 1 homolog (VMO1) by C-mannosylation. FEBS Open Bio 13, 490-499 (2023)
  9. Soda Y, Sugiyama Y, Sato S, Shibuya K, Saegusa J, Matagawa T, Kawano S, Yoritate M, Fukaya K, Urabe D, Oishi T, Mori K, Simizu S, Chida N & Sato T. Total synthesis and anti-inflammatory activity of stemoamide-type alkaloids including totally substituted butenolides and pyrroles. Synthesis 55, 617-636 (2023)
  10. Mizuta H, Takakusaki A, Suzuki T, Otake K, Dohmae N & Simizu S. C-mannosylation regulates stabilization of RAMP1 protein and RAMP1-mediated cell migration. FEBS J. 290, 196-208 (2023)
  11. Ohno O, Iwasaki A, Same K, Kudo C, Aida E, Sugiura K, Sumimoto S, Teruya T, Tashiro E, Simizu S, Matsuno K, Imoto M & Suenaga K. Isolation of caldorazole, a thiazole-containing polyketide with selective cytotoxicity under glucose-restricted conditions. Org. Lett. 24, 4547-4551 (2022)
  12. Kawano S, Matagawa T, Matsuda Y, Koyama T, Miura K, Nakata M, Saikawa Y & Simizu S. Biological evaluation of anti-inflammatory effect of africane-type sesquiterpenoids. Bioorg. Med. Chem. 68, 116857 (2022)
  13. Kamo H, Kawahara R & Simizu S. Tyrosinase suppresses vasculogenic mimicry in human melanoma cells. Oncol. Lett. 23, 169 (2022)
  14. Saegusa J, Osada Y, Miura K, Sasazawa Y, Ogura A, Takao K & Simizu S. Elucidation of structure-activity relationship of humulanolides and identification of humulanolide analog as a novel HSP90 inhibitor. Bioorg. Med. Chem. Lett. 60, 128589 (2022)
  15. Matsuda Y, Koyama T, Kawano S, Miura K, Simizu S, Saikawa Y & Nakata M. Scalable syntheses and biological evaluation of africane-type sesquiterpenoids. Chem. Biodivers. 19, e202100890 (2022)
  16. Kawahara R & Simizu S. ErbB4-mediated regulation of vasculogenic mimicry capability in breast cancer cells. Cancer Sci. 113, 950-959 (2022)
  17. Shimizu S, Kawahara R & Simizu S. Methionine aminopeptidase-2 is a pivotal regulator of vasculogenic mimicry. Oncol. Rep. 47, 31 (2022)
  18. Mori K, Sun H, Miura K & Simizu S. Involvement of DPY19L3 in myogenic differentiation of C2C12 myoblasts. Molecules 26, 5685 (2021)
  19. Mori K, Suzuki T, Miura K, Dohmae N & Simizu S. Involvement of LH3 and GLT25D1 for glucosyl-galactosyl-hydroxylation on non-collagen-like domain of FGL1. Biochem. Biophys. Res. Commun. 560, 93-98 (2021)
  20. Mizuta H, Okada K, Araki M, Adachi J, Takemoto A, Kutkowska J, Maruyama K, Yanagitani K, Oh-hara T, Watanabe K, Tamai K, Friboulet L, Katayama K, Ma B, Sasakura Y, Sagae Y, Kukimoto-Niino M, Shirouzu M, Takagi S, Simizu S, Nishio M, Okuno Y, Fujita N & Katayama R. Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer. Nature Commun. 12, 1261 (2021)
  21. Miura K, Kawano S, Suto T, Sato T, Chida N & Simizu S. Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. Bioorg. Med. Chem. 34, 116041 (2021)
  22. Yoshimoto S, Katayama K, Suzuki T, Dohmae N & Simizu S. Regulation of N-glycosylation and secretion of Isthmin-1 by its C-mannosylation. Biochim. Biophys. Acta (Gen. Subj.) 1865, 129840 (2021)
  23. Miura K, Suzuki T, Sun H, Takada H, Ishizawa Y, Mizuta H, Dohmae N & Simizu S. Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4). Biochim. Biophys. Acta (Gen. Subj.) 1865, 129833 (2021)
  24. Okuyama Y, Kidena M, Kato E, Kawano S, Ishii K, Maie K, Miura K, Simizu S, Sato T & Chida N. Seven-step synthesis of all-nitrogenated sugar derivatives using sequential Overman rearrangements. Angew. Chem. Int. Ed. 60, 5193-5198 (2021)
  25. Osada Y, Suzuki T, Mizuta H, Mori K, Miura K, Dohmae N & Simizu S. The fibrinogen C-terminal domain is seldom C-mannosylated but its C-mannosylation is important for the secretion of microfibril-associated glycoprotein 4. Biochim. Biophys. Acta (Gen. Subj.) 1864, 129637 (2020)
  26. Hayashi S, Osada Y, Miura K & Simizu S. Cell-dependent regulation of vasculogenic mimicry by carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). Biochem. Biophys. Rep. 21, 100734 (2020)
  27. Miura K, Matsuki W, Ogura A, Takao K & Simizu S. Identification of vibsanin A analog as a novel HSP90 inhibitor. Bioorg. Med. Chem. 28, 115253 (2020)
  28. Ishizawa Y, Niwa Y, Suzuki T, Kawahara R, Dohmae N & Simizu S. Identification and characterization of collagen-like glycosylation and hydroxylation of CCN1. Glycobiology 29, 696-704 (2019)
  29. Otake K, Yamada K, Miura K, Sasazawa Y, Miyazaki S, Niwa Y, Ogura A, Takao K & Simizu S. Identification of topoisomerases as molecular targets of cytosporolide C and its analog. Bioorg. Med. Chem. 27, 3334-3338 (2019)
  30. Mizuta H, Kuga K, Suzuki T, Niwa Y, Dohmae N & Simizu S. C-mannosylation of R-spondin2 activates Wnt/β-catenin signaling and migration activity in human tumor cells. Int. J. Oncol. 54, 2127-2138 (2019)
  31. Suto T, Yanagita Y, Nagashima Y, Takikawa S, Kurosu Y, Matsuo N, Miura K, Simizu S, Sato T & Chida N. Unified total synthesis of madangamine alkaloids. Bull. Chem. Soc. Jpn. 92, 545-571 (2019)
  32. Kawahara R, Niwa Y & Simizu S. Integrin β1 is an essential factor in vasculogenic mimicry of human cancer cells. Cancer Sci. 109, 2490-2496 (2018)
  33. Otani K, Niwa Y, Suzuki T, Sato N, Sasazawa Y, Dohmae N & Simizu S. Regulation of granulocyte colony-stimulating factor receptor-mediated granulocytic differentiation by C-mannosylation. Biochem. Biophys. Res. Commun. 498, 466-472 (2018)
  34. Niwa Y, Nakano Y, Suzuki T, Yamagishi M, Otani K, Dohmae N & Simizu S. Topological analysis of DPY19L3, a human C-mannosyltransferase. FEBS J. 285, 1162-1174 (2018)
  35. Matsuki W, Miyazaki S, Yoshida K, Ogura A, Sasazawa Y, Takao K & Simizu S. Synthesis and evaluation of biological activities of vibsanin A analogs. Bioorg. Med. Chem. Lett. 27, 4536-4539 (2017)
  36. Morishita S, Suzuki T, Niwa Y, Dohmae N & Simizu S. Dpy‑19 like 3‑mediated C‑mannosylation and expression levels of RPE‑spondin in human tumor cell lines. Oncol. Lett. 14, 2537-2544 (2017)
  37. Okamoto S, Murano T, Suzuki T, Uematsu S, Niwa Y, Sasazawa Y, Dohmae N, Bujo H & Simizu S. Regulation of secretion and enzymatic activity of lipoprotein lipase by C-mannosylation. Biochem. Biophys. Res. Commun. 486, 558-563 (2017)
  38. Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura S, Sato K, Harada R, Kim Y-J, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S & Harada A. Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells. J. Cell Biol. 215, 121-138 (2016)
  39. Fujiwara M, Kato S, Niwa Y, Suzuki T, Tsuchiya M, Sasazawa Y, Dohmae N & Simizu S. C-mannosylation of R-spondin3 regulates its secretion and activity of Wnt/β-catenin signaling in cells. FEBS Lett. 590, 2639-2649 (2016)
  40. Murahashi M, Simizu S, Morioka M & Umezawa K. Identification of poly(rC) binding protein 2 (PCBP2) as a target protein of immunosuppressive agent 15-deoxyspergualin. Biochem. Biophys. Res. Commun. 476, 445-449 (2016)
  41. Miyazaki S, Sasazawa Y, Mogi T, Suzuki T, Yoshida K, Dohmae N, Takao K & Simizu S. Identification of seco-clavilactone B as a novel small-molecule actin polymerization inhibitor. FEBS Lett. 590, 1163-1173 (2016)
  42. Katsuyama S, Sugino K, Sasazawa Y, Nakano Y, Aono H, Morishita K, Kawatani M, Umezawa K, Osada H & Simizu S. Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters. FEBS Lett. 590, 1152-1162 (2016)
  43. Niwa Y, Suzuki T, Dohmae N & Simizu S. Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells. Mol. Biol. Cell 27, 744-756 (2016)
  44. Tsuchiya M, Niwa Y & Simizu S. N-glycosylation of R-spondin1 at Asn137 negatively regulates its secretion and Wnt/β-catenin signaling-enhancing activity. Oncol. Lett. 11, 3279-3286 (2016)
  45. Sasazawa Y, Sato N, Suzuki T, Dohmae N & Simizu S. C-mannosylation of thrombopoietin receptor (c-Mpl) regulates thrombopoietin-dependent JAK-STAT signaling. Biochem. Biophys. Res. Commun. 468, 262-268 (2015)
  46. Iwasaki A, Ohno O, Katsuyama S, Morita M, Sasazawa Y, Dan S, Simizu S, Yamori T & Suenaga K. Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages. Bioorg. Med. Chem. Lett. 25, 5295-5298 (2015)
  47. Niwa Y, Suzuki T, Dohmae N & Simizu S. O-fucosylation of CCN1 is required for its secretion. FEBS Lett. 589, 3287–3293 (2015)
  48. Torres-Bacete J, Delgado-Martín C, Gómez-Moreira C, Simizu S & Rodríguez-Fernández JL. The mammalian sterile20-like 1 (Mst1) kinase controls selective CCR7-dependent functions in human dendritic cells. J. Immunol. 195, 973-981 (2015)
  49. Komai K, Niwa Y, Sasazawa Y & Simizu S. Pirin regulates the epithelial to mesenchymal transition independently of Bcl3-Slug signaling. FEBS Lett. 589, 738-743 (2015)
  50. Sasazawa Y, Sato N, Umezawa K & Simizu S. Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy. J. Biol. Chem. 290, 6168-6178 (2015)
  51. Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S & Umezawa K. Inhibition of MMP-2-mediated mast cell invasion by NF-κB inhibitor DHMEQ in mast cells. Int. Arch. Allergy Immunol. 166, 84-90 (2015)
  52. Kuboki M, Ito A, Simizu S & Umezawa K. Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: Involvement of positive feedback mechanism. Biochem. Biophys. Res. Commun. 456, 810-814 (2015)
  53. Uematsu S, Goto Y, Suzuki T, Sasazawa Y, Dohmae N & Simizu S. N-glycosylation of Extracellular matrix protein 1 (ECM1) regulates its secretion, which is unrelated to lipoid proteinosis. FEBS Open Bio 4, 879-885 (2014)
  54. Goto Y, Niwa Y, Suzuki T, Uematsu S, Dohmae N & Simizu S. N-glycosylation is required for secretion and enzymatic activity of human hyaluronidase1. FEBS Open Bio 4, 554-559 (2014)
  55. Goto Y, Niwa Y, Suzuki T, Dohmae N, Umezawa K & Simizu S. C-mannosylation of human hyaluronidase 1: Possible roles for secretion and enzymatic activity. Int. J. Oncol. 45, 344-350 (2014)
  56. Matsui C, Ikeda Y, Iinuma H, Kushida N, Kunisada T, Simizu S & Umezawa K. Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production. J. Antibiot. 67, 787-790 (2014)
  57. Ukaji T, Sasazawa Y, Umezawa K & Simizu S. Involvement of conserved tryptophan residues for secretion of TIMP-2. Oncol. Lett. 7, 631-634 (2014)
  58. Kuroda M, Funasaki S, Saitoh T, Sasazawa Y, Nishiyama S, Umezawa K & Simizu S. Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline. FEBS Lett. 587, 3656–3660 (2013)
  59. Ogasawara A, Simizu S, Ito A, Kawai T, Saisho Y, Takei I & Umezawa K. Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARE pathway. Biochem. Biophys. Res. Commun. 433, 181-187 (2013)
  60. Arai Y, Iinuma H, Ikeda Y, Igarashi M, Hatano M, Kinoshita N, Ukaji T, Simizu S & Umezawa K. Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp. J. Antibiot. 66, 225-230 (2013)
  61. Niwa Y, Suzuki T, Dohmae N, Umezawa K & Simizu S. Determination of cathepsin V activity and intracellular trafficking by N-glycosylation. FEBS Lett. 586, 3601-3607 (2012)
  62. Niwa Y, Matsui C, Sukumwang N, Iinuma H, Ikeda Y, Koyano T, Kovitayakorn T, Simizu S & Umezawa K. Inhibition of lysenin-induced hemolysis by all-E-lutein derived from the plant Dalbergia latifolia. Planta Med. 78, 957-961 (2012)
  63. Yasukagawa T, Niwa Y, Simizu S & Umezawa K. Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells. FEBS Lett. 586, 1504-1509 (2012)
  64. Noma N, Simizu S, Kambayashi Y, Kabe Y, Suematsu M & Umezawa K. Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced brest cancer cell adhesion. Oncol. Rep. 27, 2080-2084 (2012)
  65. Khan MGM, Simizu S, Suzuki T, Masuda A, Muroi M, Kawatani M, Dohmae N & Osada H. Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-9. Exp. Cell Res. 318, 904-914 (2012)
  66. Takeiri M, Horie K, Takahashi D, Watanabe M, Horie R, Simizu S & Umezawa K. Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB. Org. Biomol. Chem. 10, 3053-3059 (2012)
  67. Hirai G, Tsuchiya A, Koyama Y, Otani Y, Oonuma K, Dodo K, Simizu S, Osada H & Sodeoka M. Development of a vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure. ChemMedChem 6, 617-622 (2011)
  68. Khan MGM, Simizu S, Lai NS, Kawatani M, Shimizu T & Osada H. Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120. ACS Chem. Biol. 6, 245-251 (2011)
  69. Miyanishi N, Suzuki Y, Simizu S, Kuwabara Y, Banno K & Umezawa K. Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion. Biochem. Biophys. Res. Commun. 403, 154-159 (2010)
  70. Miyazaki I, Simizu S, Okumura H, Takagi S & Osada H. A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Nature Chem. Biol. 6, 667-673 (2010)
  71. Kanoh N, Takayama H, Honda K, Moriya T, Teruya T, Simizu S, Osada H & Iwabuchi Y. Cleavable linker for photo-cross-linked small-molecule affinity matrix. Bioconjugate Chem. 21, 182-186 (2010)
  72. Simizu S, Teruya T, Nogawa T, Aono H, Ueki M, Uramoto M, Kobayashi Y & Osada H. Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells. Biochem. Biophys. Res. Commun. 383, 406-410 (2009)
  73. Miyazaki I, Okumura H, Simizu S, Takahashi Y, Kanoh N, Muraoka Y, Nonomura Y & Osada H. Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array. ChemBioChem 10, 845-852 (2009)
  74. Miyazaki I, Simizu S, Ishida K & Osada H. On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors. ChemBioChem 10, 838-843 (2009)
  75. Takagi S, Simizu S & Osada H. RECK negatively regulates matrix metalloproteinase-9 transcription. Cancer Res. 69, 1502-1508 (2009)
  76. Asami Y, Mori M, Koshino H, Sekiyama Y, Teruya T, Simizu S, Usui T & Osada H. A cell-based screening to detect inhibitors of BRAF signaling pathway. J. Antibiot. 62, 105-107 (2009)
  77. Tamura Y, Simizu S, Muroi M, Takagi S, Kawatani M, Watanabe N & Osada H. Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis. Oncogene 28, 107-116 (2009)
  78. Miyazaki I, Simizu S, Ichimiya H, Kawatani M & Osada H. Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II. Biosci. Biotechnol. Biochem. 72, 2739-2749 (2008) (B.B.B. Excellent Paper Award)
  79. Lai NS, Simizu S, Morisaki D, Muroi M & Osada H. Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase. Exp. Cell Res. 314, 2834-2845 (2008)
  80. Miyazaki T, Yokoshima S, Simizu S, Osada H, Tokuyama H & Fukuyama T. Synthesis of (+)-vinblastine and its analogues. Org. Lett. 9, 4737-4740 (2007)
  81. Simizu S, Suzuki T, Muroi M, Lai NS, Takagi S, Dohmae N & Osada H. Involvement of disulfide bond formation in the activation of heparanase. Cancer Res. 67, 7841-7849 (2007)
  82. Kanoh N, Asami A, Kawatani M, Honda K, Kumashiro S, Takayama H, Simizu S, Amemiya T, Kondoh Y, Hatakeyama S, Tsuganezawa K, Utata R, Tanaka A, Yokoyama S, Tashiro H & Osada H. Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions. Chem. Asian J. 1, 789-797 (2006)
  83. Simizu S, Takagi S, Tamura Y & Osada H. RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. Cancer Res. 65, 7455-7461 (2005)
  84. Kanoh N, Honda K, Simizu S, Muroi M & Osada H. Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics. Angew. Chem. Int. Ed. 44, 3559-3562 (2005)
  85. Teruya T, Simizu S, Kanoh N & Osada H. Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells. FEBS Lett. 579, 2463-2468 (2005)
  86. Ishida K, Hirai G, Murakami K, Teruya T, Simizu S, Sodeoka M & Osada H. Structure-based design of a selective heparanase inhibitor as an antimetastatic agent. Mol. Cancer Ther. 3, 1069-1077 (2004)
  87. Tamura Y, Simizu S & Osada H. The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria. FEBS Lett. 569, 249-255 (2004)
  88. Kondoh M, Suzuki I, Sato M, Nagashima F, Simizu S, Harada M, Fujii M, Osada H, Asakawa Y & Watanabe Y. Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway. J. Pharmacol. Exp. Ther. 311, 115-122 (2004)
  89. Ishida K, Simizu S, Teruya T, Wierzba MK & Osada H. Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents. Bioorg. Med. Chem. Lett. 14, 2505-2509 (2004)
  90. Simizu, S., Tamura, Y. & Osada, H. Dephosphorylation of Bcl-2 by protein phosphatase 2A results in apoptosis resistance. Cancer Sci. 95, 266-270 (2004)
  91. Ishida, K., Teruya, T., Simizu, S. & Osada, H. Exploitation of heparanase inhibitors from microbial metabolites using an efficient visual screening system. J. Antibiot. 57, 136-142 (2004)
  92. Ishida, K., Wierzba, M. K., Teruya, T., Simizu, S. & Osada, H. Novel heparan sulfate mimetic compounds as antitumor agents. Chem. Biol. 11, 367-377 (2004)
  93. Simizu, S., Ishida, K., Wierzba, M. K. & Osada, H. Secretion of heparanase protein is regulated by glycosylation in human tumor cell lines. J. Biol. Chem. 279, 2697-2703 (2004)
  94. Kanoh, N., Kumashiro, S., Simizu, S., Kondoh, Y., Hatakeyama, S., Tashiro, H. & Osada, H. Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions. Angew. Chem. Int. Ed. 42, 5584-5587 (2003)
  95. Nagashima, F., Kondoh, M., Kawase, M., Simizu, S., Osada, H., Fujii, M., Watanabe, Y., Sato, M. & Asakawa, Y. Apoptosis-inducing properties of ent-kaurene-type diterpenoids from the liverwort Jungermannia truncata. Planta Med. 69, 377-379 (2003)
  96. Kawatani, M., Uchi, M., Simizu, S., Osada, H. & Imoto, M. Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis. Exp. Cell Res. 286, 57-66 (2003)
  97. Simizu, S., Ishida, K., Wierzba, M. K., Sato, T.-A. & Osada, H. Expression of heparanase in human tumor cell lines and human head and neck tumors. Cancer Lett. 193, 83-89 (2003)
  98. Matsumoto, Y., Kawatani, M., Simizu, S., Tanaka, T., Takada, M. & Imoto, M. Bcl-2-independent induction of apoptosis by neuropeptide receptor antagonist in human small cell lung carcinoma cells. Anticancer Res. 20, 3123-3129 (2000)
  99. Kawatani, M., Simizu, S., Osada, H., Takada, M., Arber, N. & Imoto, M. Involvement of protein kinase C-regulated ceramide generation in inostamycin-induced apoptosis. Exp. Cell Res. 259, 389-397 (2000)
  100. Simizu, S. & Osada, H. Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines. Nature Cell Biol. 2, 852-854 (2000)
  101. Simizu, S., Shibasaki, F. & Osada, H. Bcl-2 inhibits calcineurin-mediated Fas ligand expression in antitumor drug-treated baby hamster kidney cells. Jpn. J. Cancer Res. 91, 706-714 (2000)
  102. Simizu, S., Takada, M., Umezawa, K. & Imoto, M. Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs. J. Biol. Chem. 273, 26900-26907 (1998)
  103. Simizu, S., Tanabe, K., Tashiro, E., Takada, M., Umezawa, K. & Imoto, M. Potentiation of paclitaxel cytotoxicity by inostamycin in human small cell lung carcinoma, Ms-1 cells. Jpn. J. Cancer Res. 89, 970-976 (1998)
  104. Tashiro, E., Simizu, S., Takada, M., Umezawa, K. & Imoto, M. Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small cell lung carcinoma Ms-1 cells. Jpn. J. Cancer Res. 89, 940-946 (1998)
  105. Imoto, M., Tanabe, K., Simizu, S., Tashiro, E., Takada, M. & Umezawa, K. Inhibition of cyclin D1 expression and induction of apoptosis by inostamycin in small cell lung carcinoma cells. Jpn. J. Cancer Res. 89, 315-322 (1998)
  106. Simizu, S., Umezawa, K., Takada, M., Arber, N. & Imoto, M. Induction of hydrogen peroxide production and Bax expression by caspase-3(-like) proteases in tyrosine kinase inhibitor-induced apoptosis in human small cell lung carcinoma cells. Exp. Cell Res. 238, 197-203 (1998)
  107. Simizu, S., Imoto, M., Masuda, N., Takada, M. & Umezawa, K. Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. Cancer Res. 56, 4978-4982 (1996)
  108. Simizu, S., Imoto, M. & Umezawa, K. Induction of apoptosis by erbstatin in mouse leukemia L1210 cells. Biosci. Biotechnol. Biochem. 58, 1549-1552 (1994)

Review Articles

  1. Simizu S. Vasculogenic mimicry: A dynamic event of malignancys. Biochim. Biophys. Acta (gen. Subj) 1866, 130084 (2022)(Editorial)
  2. Takao K, Ogura A, Yoshida K, & Simizu S. Total synthesis of natural products using intramolecular Nozaki-Hiyama-Takai-Kishi reactions. Synlett 31, 421-433 (2020)
  3. Niwa Y, & Simizu S. C-mannosylation: previous studies and future research perspectives. Trends Glycosci. Glycotechnol. 30, E231-E238 (2018)
  4. Umezawa K, Kojima I, Simizu S, Lin Y, Fukatsu H, Koide N, Nakade Y & Yoneda M. Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegerative disease models. Human Cell 31, 95-101 (2018)
  5. Simizu S & Niwa Y. Molecular targets for suppression of metastasis: recent cellular observations. For. Immunopathol. Dis. Ther. 4, 43-51 (2013)
  6. Khan MGM, Simizu S, Kawatani M & Osada H. The potential of protein disulfide isomerase as a therapeutic drug target. Oncol. Res. 19, 445-453 (2012)
  7. Miyazaki I, Simizu S & Osada H. The application of the chemical array for biological study. Methods Mol. Biol. 669, 95-107 (2010)
  8. Simizu S, Ishida K & Osada H. Heparanase as a molecular target of cancer chemotherapy. Cancer Sci. 95, 553-558 (2004)

Review Articles in Japanese

  1. 丹羽祐貴、清水史郎「C-マンノシル化のこれまでの研究動向と今後の研究展望」Trends Glycosci. Glycotechnol., 30, J191-J198 (2018)
  2. 叶直樹、清水史郎「化合物アレイを起点としたケミカルバイオロジー 化合物アレイの基盤技術開発から機能未知タンパク質の機能解析まで」化学と工業, 64, 37-39 (2011)
  3. 宮崎功、奥村英夫、清水史郎、長田裕之「小分子化合物TPh Aを用いた初のピリン機能解明」実験医学, 29, 79-83 (2011)
  4. 清水史郎、辻田和彦、長田裕之「分子細胞学的解析」日本臨牀, 67増刊号1, 143-147 (2009)
  5. 清水史郎、長田裕之「バイオプローブ開発からケミカルバイオロジー研究へ」化学工業, 58, 335-339 (2007)
  6. 叶直樹、清水史郎、臼井健郎、長田裕之「天然由来のバイオプローブを用いたケミカルジェネティクスとケミカルゲノミクス」蛋白質 核酸 酵素, 50, 1037-1042 (2005)
  7. 臼井健郎、叶直樹、清水史郎、長田裕之「バイオプローブの探索と細胞内標的分子の同定」実験医学, 23, 1803-1809 (2005)
  8. 清水史郎「2004年度日本癌学会奨励賞―薬剤耐性･転移に関与するがん分子標的の機能解析」Medical Academy NEWS, 929, 6 (2005)
  9. 清水史郎、長田裕之「微小管作用薬の抗がん作用」分子細胞治療, 2, 364-369 (2001)
  10. 長田裕之、浜本隆二、清水史郎「進化する抗がん剤―第４回がん分子標的治療研究会見聞録」化学と生物, 38, 799-803 (2000)
  11. 清水史郎「抗腫瘍物質による細胞死の誘導機構」バイオサイエンスとインダストリー, 56, 747-750 (1998)
  12. 井本正哉、清水史郎、梅沢一夫「チロシンキナーゼ阻害剤のアポトーシス誘導機構」日本農芸化学会誌, 71, 523-526 (1997)

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